InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fancm

Summary

InnateDB Protein

IDBP-143250.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fancm

Protein Name

Fanconi anemia, complementation group M

Synonyms

AI427100; C730036B14Rik; D12Ertd364e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000054797

InnateDB Gene

IDBG-143248 (Fancm)

Protein Structure

UniProt Annotation

Function

ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0004386	helicase activity
GO:0004518	nuclease activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity

Biological Process

GO:0000712	resolution of meiotic recombination intermediates
GO:0006281	DNA repair
GO:0031297	replication fork processing
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005634	nucleus
GO:0043240	Fanconi anaemia nuclear complex
GO:0071821	FANCM-MHF complex

Protein Structure and Domains

PDB ID

MGI:2442306

InterPro

IPR001650 Helicase, C-terminal
IPR006166 ERCC4 domain
IPR006935 Helicase/UvrB domain
IPR010994 RuvA domain 2-like
IPR011335 Restriction endonuclease type II-like
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF02732
PF04851
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00891
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BGE5