Mus musculus Protein: Fancm
Summary
InnateDB Protein IDBP-143250.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fancm
Protein Name Fanconi anemia, complementation group M
Synonyms AI427100; C730036B14Rik; D12Ertd364e;
Species Mus musculus
Ensembl Protein ENSMUSP00000054797
InnateDB Gene IDBG-143248 (Fancm)
Protein Structure
UniProt Annotation
Function ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0004386 helicase activity
GO:0004518 nuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Biological Process
GO:0000712 resolution of meiotic recombination intermediates
GO:0006281 DNA repair
GO:0031297 replication fork processing
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0043240 Fanconi anaemia nuclear complex
GO:0071821 FANCM-MHF complex
Protein Structure and Domains
PDB ID MGI:2442306
InterPro IPR001650 Helicase, C-terminal
IPR006166 ERCC4 domain
IPR006935 Helicase/UvrB domain
IPR010994 RuvA domain 2-like
IPR011335 Restriction endonuclease type II-like
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00271
PF02732
PF04851
PF00270
PRINTS
PIRSF
SMART SM00490
SM00891
SM00487
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BGE5
PhosphoSite PhosphoSite-Q8BGE5
TrEMBL
UniProt Splice Variant
Entrez Gene 104806
UniGene Mm.374847
RefSeq NP_849243
MGI ID
MGI Symbol Fancm
OMIM
CCDS CCDS25941
HPRD
IMGT
EMBL AK050306 AK053715 AK084697 AK086395 AK173211
GenPept BAC34178 BAC35487 BAC39257 BAC39660 BAD32489