Version 5.4
Mus musculus Gene: Fancm
Summary
InnateDB Gene IDBG-143248.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fancm
Gene Name Fanconi anemia, complementation group M
Synonyms AI427100; C730036B14Rik; D12Ertd364e
Species Mus musculus
Ensembl Gene ENSMUSG00000055884
Encoded Proteins
IDBP-143250
Fanconi anemia, complementation group M
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187790:
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:65075606-65132058
Strand Forward strand
Band C1
Transcripts
ENSMUST00000058889 ENSMUSP00000054797
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0004386 helicase activity
GO:0004518 nuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Biological Process
GO:0000712 resolution of meiotic recombination intermediates
GO:0006281 DNA repair
GO:0031297 replication fork processing
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0043240 Fanconi anaemia nuclear complex
GO:0071821 FANCM-MHF complex
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000187790
View Gene Order
Pathways
NETPATH
REACTOME
REACT_233397
DNA Repair pathway
REACT_232842
Fanconi Anemia pathway pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18410
Fanconi Anemia pathway pathway
REACT_216
DNA Repair pathway
KEGG
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
Cross-References
SwissProt Q8BGE5
TrEMBL
UniProt Splice Variant
Entrez Gene 104806
UniGene Mm.374847
RefSeq NM_178912
OMIM
CCDS CCDS25941
HPRD
IMGT
MGI ID MGI:2442306
MGI Symbol Fancm
EMBL AK050306 AK053715 AK084697 AK086395 AK173211
GenPept BAC34178 BAC35487 BAC39257 BAC39660 BAD32489
RNA Seq Atlas 104806

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca