Version 5.4
Mus musculus Protein: Insig1
Summary
InnateDB Protein IDBP-144023.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Insig1
Protein Name insulin induced gene 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000061877
InnateDB Gene IDBG-144021 (Insig1)
Protein Structure
UniProt Annotation
Function Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006641 triglyceride metabolic process
GO:0006695 cholesterol biosynthetic process
GO:0006991 response to sterol depletion
GO:0008203 cholesterol metabolic process
GO:0010894 negative regulation of steroid biosynthetic process
GO:0016126 sterol biosynthetic process
GO:0032933 SREBP signaling pathway
GO:0042472 inner ear morphogenesis
GO:0042474 middle ear morphogenesis
GO:0045599 negative regulation of fat cell differentiation
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0060021 palate development
GO:0060363 cranial suture morphogenesis
GO:1901303 negative regulation of cargo loading into COPII-coated vesicle
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0032937 SREBP-SCAP-Insig complex
Protein Structure and Domains
PDB ID MGI:1916289
InterPro IPR025929 Insulin-induced protein family
PFAM PF07281
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BGI3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 231070
UniGene Mm.470370
RefSeq NP_705746
MGI ID
MGI Symbol Insig1
OMIM
CCDS CCDS19142
HPRD
IMGT
EMBL AF527630 AK088380 AK135941 AK139913 AK151186 BC132167 BC132499
GenPept AAI32168 AAI32500 AAN28331 BAC40316 BAE22733 BAE24179 BAE30185

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca