Version 5.4
Mus musculus Protein: Ewsr1
Summary
InnateDB Protein IDBP-144121.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ewsr1
Protein Name Ewing sarcoma breakpoint region 1
Synonyms Ews; Ewsh;
Species Mus musculus
Ensembl Protein ENSMUSP00000078867
InnateDB Gene IDBG-144115 (Ewsr1)
Protein Structure
UniProt Annotation
Function Might function as a transcriptionnal repressor. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
They are also associated with 184 interaction(s) predicted by orthology.
Experimentally validated
Total 67 [view]
Protein-Protein 67 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 184 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0008270 zinc ion binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:99960
InterPro IPR000504 RNA recognition motif domain
IPR001876 Zinc finger, RanBP2-type
PFAM PF00076
PF00641
PRINTS
PIRSF
SMART SM00360
SM00547
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61545
PhosphoSite PhosphoSite-Q61545
TrEMBL Q6NVA3
UniProt Splice Variant
Entrez Gene 14030
UniGene Mm.399275
RefSeq NP_031994
MGI ID
MGI Symbol Ewsr1
OMIM
CCDS CCDS24396
HPRD
IMGT
EMBL AK019460 AK147909 AK150345 AK151625 AK153276 AL645845 BC068226 CH466574 X79233
GenPept AAH68226 BAB31732 BAE28221 BAE29484 BAE30560 BAE31862 CAA55815 CAI25231 EDL40519

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca