Version 5.4
Mus musculus Protein: Prpf4b
Summary
InnateDB Protein IDBP-144281.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prpf4b
Protein Name PRP4 pre-mRNA processing factor 4 homolog B (yeast)
Synonyms 2610037H07; cbp143; Prp4; Prp4k; Prpk;
Species Mus musculus
Ensembl Protein ENSMUSP00000077019
InnateDB Gene IDBG-144277 (Prpf4b)
Protein Structure
UniProt Annotation
Function Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID MGI:109584
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61136
PhosphoSite PhosphoSite-Q61136
TrEMBL Q8C5G1
UniProt Splice Variant
Entrez Gene 19134
UniGene Mm.417570
RefSeq NP_038858
MGI ID
MGI Symbol Prpf4b
OMIM
CCDS CCDS26448
HPRD
IMGT
EMBL AB516304 AF033663 AF283466 AK020579 AK021274 AK076020 AK078611 AK083926 BC141272 BC141273 CH466546 U48737
GenPept AAB03269 AAC32042 AAI41273 AAI41274 AAM19102 BAB32137 BAB32358 BAC36125 BAC37340 BAC39069 BAI22793 EDL40895

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca