InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MIB1

Summary

InnateDB Protein

IDBP-1443.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MIB1

Protein Name

mindbomb homolog 1 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000261537

InnateDB Gene

IDBG-1441 (MIB1)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF- induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. {ECO:0000250, ECO:0000269PubMed:24121310}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:24121310}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269PubMed:24121310}. Cell membrane {ECO:0000250}. Note=Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock. {ECO:0000250}.

Disease Associations

Left ventricular non-compaction 7 (LVNC7) [MIM:615092]: A disease due to an arrest of myocardial morphogenesis. It is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies. {ECO:0000269PubMed:23314057}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined. {ECO:0000269PubMed:10718198}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	45 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0001568	blood vessel development
GO:0001701	in utero embryonic development
GO:0001756	somitogenesis
GO:0001841	neural tube formation
GO:0001947	heart looping
GO:0007219	Notch signaling pathway
GO:0007507	heart development
GO:0016567	protein ubiquitination
GO:0045665	negative regulation of neuron differentiation
GO:0045807	positive regulation of endocytosis

Cellular Component

GO:0005813	centrosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0031410	cytoplasmic vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR000433 Zinc finger, ZZ-type
IPR001841 Zinc finger, RING-type
IPR002110 Ankyrin repeat
IPR010606 Mib-herc2
IPR020683 Ankyrin repeat-containing domain

PFAM