Homo sapiens Gene: MIB1
Summary
InnateDB Gene IDBG-1441.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MIB1
Gene Name mindbomb E3 ubiquitin protein ligase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101752
Encoded Proteins
mindbomb homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 18:21704957-21870957
Strand Forward strand
Band q11.2
Transcripts
ENST00000261537 ENSP00000261537
ENST00000578260
ENST00000578646
ENST00000577749
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 45 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0001568 blood vessel development
GO:0001701 in utero embryonic development
GO:0001756 somitogenesis
GO:0001841 neural tube formation
GO:0001947 heart looping
GO:0007219 Notch signaling pathway
GO:0007507 heart development
GO:0016567 protein ubiquitination
GO:0045665 negative regulation of neuron differentiation
GO:0045807 positive regulation of endocytosis
Cellular Component
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Constitutive Signaling by NOTCH1 HD Domain Mutants pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Signaling by NOTCH1 in Cancer pathway
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signal Transduction pathway
Signaling by NOTCH2 pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Activated NOTCH1 Transmits Signal to the Nucleus pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Notch signaling pathway
Cross-References
SwissProt Q86YT6
TrEMBL B3KRA8
UniProt Splice Variant
Entrez Gene 57534
UniGene Hs.140903 Hs.603914 Hs.706963 Hs.712806
RefSeq NM_020774
HUGO HGNC:21086
OMIM 608677
CCDS CCDS11871
HPRD
IMGT
EMBL AB037744 AK075157 AK091266 AL713705 AY147849 AY149908 BC022403 BC110581 BC110582 CR749635 EF444995
GenPept AAH22403 AAI10582 AAI10583 AAN18023 AAN75493 ACA06016 BAA92561 BAC11439 BAG52320 CAD28502 CAH18429
RNA Seq Atlas 57534