InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gnl3

Summary

InnateDB Protein

IDBP-144364.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gnl3

Protein Name

guanine nucleotide binding protein-like 3 (nucleolar)

Synonyms

Ns;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047119

InnateDB Gene

IDBG-144362 (Gnl3)

Protein Structure

UniProt Annotation

Function

May be required to maintain the proliferative capacity of stem cells (By similarity). Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation. {ECO:0000250, ECO:0000269PubMed:21132010}.

Subcellular Localization

Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Shuttles between the nucleus and nucleolus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the adult bone marrow population that is enriched in hematopoietic stem cells. {ECO:0000269PubMed:12464630}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0008283	cell proliferation
GO:0042127	regulation of cell proliferation
GO:0042254	ribosome biogenesis

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1353651

InterPro

IPR014813 Guanine nucleotide-binding protein-like 3, N-terminal domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF08701

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CI11

PhosphoSite

PhosphoSite-Q8CI11

TrEMBL

UniProt Splice Variant

Entrez Gene

30877

UniGene

Mm.88512

RefSeq

NP_705775

MGI ID

MGI Symbol

Gnl3

OMIM

CCDS

CCDS26905

HPRD

IMGT

EMBL

AK077523 AY181025 AY185498 BC037996

GenPept

AAH37996 AAO19472 AAO19473 BAC36844