Version 5.4
Mus musculus Protein: Tyms
Summary
InnateDB Protein IDBP-145032.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tyms
Protein Name thymidylate synthase
Synonyms Ts;
Species Mus musculus
Ensembl Protein ENSMUSP00000026846
InnateDB Gene IDBG-145030 (Tyms)
Protein Structure
UniProt Annotation
Function Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003729 mRNA binding
GO:0004799 thymidylate synthase activity
GO:0005542 folic acid binding
GO:0008144 drug binding
GO:0042803 protein homodimerization activity
GO:0048037 cofactor binding
Biological Process
GO:0005976 polysaccharide metabolic process
GO:0006206 pyrimidine nucleobase metabolic process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0007568 aging
GO:0007623 circadian rhythm
GO:0009636 response to toxic substance
GO:0014070 response to organic cyclic compound
GO:0019088 immortalization of host cell by virus
GO:0019860 uracil metabolic process
GO:0031100 organ regeneration
GO:0032259 methylation
GO:0032570 response to progesterone
GO:0033189 response to vitamin A
GO:0034097 response to cytokine
GO:0042493 response to drug
GO:0045471 response to ethanol
GO:0046078 dUMP metabolic process
GO:0046653 tetrahydrofolate metabolic process
GO:0046683 response to organophosphorus
GO:0048589 developmental growth
GO:0051216 cartilage development
GO:0051384 response to glucocorticoid
GO:0051593 response to folic acid
GO:0060574 intestinal epithelial cell maturation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID MGI:98878
InterPro IPR000398 Thymidylate synthase
IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain
PFAM PF00303
PRINTS PR00108
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P07607
PhosphoSite PhosphoSite-P07607
TrEMBL Q8K1U2
UniProt Splice Variant
Entrez Gene 22171
UniGene Mm.268395
RefSeq NP_067263
MGI ID 4EZ8
MGI Symbol Tyms
OMIM
CCDS CCDS19154
HPRD
IMGT
EMBL AK035663 AK088606 CH466524 J02617 M13019 M13347 M13348 M13349 M13350 M13351 M13352 X12983 X14489
GenPept AAA40439 AAA40444 BAC29144 BAC40450 CAA31422 CAA32651 EDL37260

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca