InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tyms

Summary

InnateDB Gene

IDBG-145030.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tyms

Gene Name

thymidylate synthase

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025747

Encoded Proteins

IDBP-145032

thymidylate synthase

IDBP-537266

thymidylate synthase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an enzyme that catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate as a cofactor. This function maintains the thymidine-5-prime monophosphate concentration critical for DNA replication and repair. The encoded enzyme is a target for cancer chemotherapeutic agents. The majority of transcripts for this gene lack a 3' UTR (PMID: 3022294, 3444407). The stop codon in these transcripts is UAA, compared to the UAG found in the genome and longer transcripts, as the polyA site is located within the stop codon (PMID: 3444407, 2157203). A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Mar 2010]
This gene encodes an enzyme that catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate as a cofactor. This function maintains the thymidine-5-prime monophosphate concentration critical for DNA replication and repair. The encoded enzyme is a target for cancer chemotherapeutic agents. The majority of transcripts for this gene lack a 3\' UTR (PMID: 3022294, 3444407). The stop codon in these transcripts is UAA, compared to the UAG found in the genome and longer transcripts, as the polyA site is located within the stop codon (PMID: 3444407, 2157203). A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:30058202-30073617

Strand

Reverse strand

Band

Transcripts

ENSMUST00000026846	ENSMUSP00000026846
ENSMUST00000141630	ENSMUSP00000123377
ENSMUST00000146520
ENSMUST00000134298
ENSMUST00000138520
ENSMUST00000154751

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003729	mRNA binding
GO:0004799	thymidylate synthase activity
GO:0005542	folic acid binding
GO:0008144	drug binding
GO:0042803	protein homodimerization activity
GO:0048037	cofactor binding

Biological Process

GO:0005976	polysaccharide metabolic process
GO:0006206	pyrimidine nucleobase metabolic process
GO:0006231	dTMP biosynthetic process
GO:0006235	dTTP biosynthetic process
GO:0007568	aging
GO:0007623	circadian rhythm
GO:0009636	response to toxic substance
GO:0014070	response to organic cyclic compound
GO:0019088	immortalization of host cell by virus
GO:0019860	uracil metabolic process
GO:0031100	organ regeneration
GO:0032259	methylation
GO:0032570	response to progesterone
GO:0033189	response to vitamin A
GO:0034097	response to cytokine
GO:0042493	response to drug
GO:0045471	response to ethanol
GO:0046078	dUMP metabolic process
GO:0046653	tetrahydrofolate metabolic process
GO:0046683	response to organophosphorus
GO:0048589	developmental growth
GO:0051216	cartilage development
GO:0051384	response to glucocorticoid
GO:0051593	response to folic acid
GO:0060574	intestinal epithelial cell maturation