InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atl1

Summary

InnateDB Protein

IDBP-145177.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atl1

Protein Name

atlastin GTPase 1

Synonyms

4930435M24Rik; Adfsp; Fsp1; Spg3; Spg3a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021466

InnateDB Gene

IDBG-145175 (Atl1)

Protein Structure

UniProt Annotation

Function

GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0042802	identical protein binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007029	endoplasmic reticulum organization
GO:0007409	axonogenesis
GO:0051260	protein homooligomerization

Cellular Component

GO:0000137	Golgi cis cisterna
GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0030424	axon

Protein Structure and Domains

PDB ID

MGI:1921241

InterPro

IPR003191 Guanylate-binding protein, C-terminal
IPR015894 Guanylate-binding protein, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02841
PF02263

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BH66

PhosphoSite