InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bap1

Summary

InnateDB Protein

IDBP-145804.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bap1

Protein Name

Brca1 associated protein 1

Synonyms

2300006C11Rik; AA989761; AW553466; mKIAA0272; uch-x4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022458

InnateDB Gene

IDBG-145802 (Bap1)

Protein Structure

UniProt Annotation

Function

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'- linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration. Acts as a tumor suppressor (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly nuclear. Binds to chromatin. Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in mammary glands, testis and ovary. Up-regulated in mammary glands during puberty, pregnancy, and as a result of parity. {ECO:0000269PubMed:9528852}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding

Biological Process

GO:0001558	regulation of cell growth
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0008285	negative regulation of cell proliferation
GO:0016579	protein deubiquitination
GO:0035520	monoubiquitinated protein deubiquitination
GO:0035522	monoubiquitinated histone H2A deubiquitination
GO:0051726	regulation of cell cycle
GO:0071108	protein K48-linked deubiquitination

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0035517	PR-DUB complex

Protein Structure and Domains

PDB ID

MGI:1206586

InterPro

IPR001578 Peptidase C12, ubiquitin carboxyl-terminal hydrolase

PFAM

PF01088

PRINTS

PR00707

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99PU7

PhosphoSite

PhosphoSite-Q99PU7

TrEMBL

UniProt Splice Variant

Entrez Gene

104416

UniGene

RefSeq

NP_081364

MGI ID

MGI Symbol

Bap1

OMIM

CCDS

CCDS26910

HPRD

IMGT

EMBL

AB047820 AK129108 AK170576 BC050901

GenPept

AAH50901 BAB32976 BAC97918 BAE41889