Mus musculus Gene: Bap1
Summary
InnateDB Gene IDBG-145802.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bap1
Gene Name Brca1 associated protein 1
Synonyms 2300006C11Rik; AA989761; AW553466; mKIAA0272; uch-x4;
Species Mus musculus
Ensembl Gene ENSMUSG00000021901
Encoded Proteins
Brca1 associated protein 1
Brca1 associated protein 1
Brca1 associated protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163930:
The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene. [provided by RefSeq, Jul 2008]
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:31251450-31259944
Strand Forward strand
Band B
Transcripts
ENSMUST00000022458 ENSMUSP00000022458
ENSMUST00000188714
ENSMUST00000189834
ENSMUST00000190788
ENSMUST00000188453 ENSMUSP00000139824
ENSMUST00000187156 ENSMUSP00000139903
ENSMUST00000185987
ENSMUST00000185700
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
Biological Process
GO:0001558 regulation of cell growth
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008285 negative regulation of cell proliferation
GO:0016579 protein deubiquitination
GO:0035520 monoubiquitinated protein deubiquitination
GO:0035522 monoubiquitinated histone H2A deubiquitination
GO:0051726 regulation of cell cycle
GO:0071108 protein K48-linked deubiquitination
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0035517 PR-DUB complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q99PU7
TrEMBL
UniProt Splice Variant
Entrez Gene 104416
UniGene
RefSeq NM_027088
OMIM
CCDS CCDS26910
HPRD
IMGT
MGI ID MGI:1206586
MGI Symbol Bap1
EMBL AB047820 AK129108 AK170576 BC050901
GenPept AAH50901 BAB32976 BAC97918 BAE41889
RNA Seq Atlas 104416