InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adrb3

Summary

InnateDB Protein

IDBP-145894.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adrb3

Protein Name

adrenergic receptor, beta 3

Synonyms

Adrb-3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080162

InnateDB Gene

IDBG-145892 (Adrb3)

Protein Structure

UniProt Annotation

Function

Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

White and brown adipose tissues, and digestive tract. Isoform B highest in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004939	beta-adrenergic receptor activity
GO:0005515	protein binding
GO:0015052	beta3-adrenergic receptor activity
GO:0031699	beta-3 adrenergic receptor binding
GO:0042803	protein homodimerization activity
GO:0051379	epinephrine binding
GO:0051380	norepinephrine binding

Biological Process

GO:0002024	diet induced thermogenesis
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007568	aging
GO:0009409	response to cold
GO:0031649	heat generation
GO:0040015	negative regulation of multicellular organism growth
GO:0042755	eating behavior
GO:0043410	positive regulation of MAPK cascade
GO:0046677	response to antibiotic
GO:0050873	brown fat cell differentiation
GO:0071875	adrenergic receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

MGI:87939

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000681 Beta 3 adrenoceptor
IPR002232 5-Hydroxytryptamine 6 receptor
IPR002233 Adrenoceptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00563
PR01102
PR01103

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P25962