InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Adrb3

Summary

InnateDB Gene

IDBG-145892.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adrb3

Gene Name

adrenergic receptor, beta 3

Synonyms

Adrb-3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031489

Encoded Proteins

IDBP-145894

adrenergic receptor, beta 3

IDBP-401472

adrenergic receptor, beta 3

IDBP-401471

adrenergic receptor, beta 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188778:
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:27225776-27229588

Strand

Reverse strand

Band

Transcripts

ENSMUST00000081438	ENSMUSP00000080162
ENSMUST00000121838	ENSMUSP00000113006
ENSMUST00000117565	ENSMUSP00000113732

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004939	beta-adrenergic receptor activity
GO:0005515	protein binding
GO:0015052	beta3-adrenergic receptor activity
GO:0031699	beta-3 adrenergic receptor binding
GO:0042803	protein homodimerization activity
GO:0051379	epinephrine binding
GO:0051380	norepinephrine binding

Biological Process

GO:0002024	diet induced thermogenesis
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007568	aging
GO:0009409	response to cold
GO:0031649	heat generation
GO:0040015	negative regulation of multicellular organism growth
GO:0042755	eating behavior
GO:0043410	positive regulation of MAPK cascade
GO:0046677	response to antibiotic
GO:0050873	brown fat cell differentiation
GO:0071875	adrenergic receptor signaling pathway