InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SOCS1

Summary

InnateDB Protein

IDBP-14623.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOCS1

Protein Name

suppressor of cytokine signaling 1

Synonyms

CIS1; CISH1; JAB; SOCS-1; SSI-1; SSI1; TIP3;

Species

Homo sapiens

Ensembl Protein

ENSP00000329418

InnateDB Gene

IDBG-14621 (SOCS1)

Protein Structure

UniProt Annotation

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. {ECO:0000250, ECO:0000269PubMed:11278610, ECO:0000269PubMed:11313480}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16410555}. Cytoplasmic vesicle {ECO:0000269PubMed:16410555}. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.

Disease Associations

Tissue Specificity

Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 84 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	84 [view]
Protein-Protein	75 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004860	protein kinase inhibitor activity
GO:0005159	insulin-like growth factor receptor binding
GO:0005515	protein binding
GO:0019210	kinase inhibitor activity
GO:0019901	protein kinase binding

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0007259	JAK-STAT cascade
GO:0016567	protein ubiquitination
GO:0019221	cytokine-mediated signaling pathway
GO:0035556	intracellular signal transduction
GO:0040008	regulation of growth
GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0045087	innate immune response (InnateDB)
GO:0045444	fat cell differentiation
GO:0046426	negative regulation of JAK-STAT cascade
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060334	regulation of interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0071230	cellular response to amino acid stimulus