InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: YWHAE

Summary

InnateDB Protein

IDBP-14631.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YWHAE

Protein Name

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

Synonyms

14-3-3E; HEL2; KCIP-1; MDCR; MDS;

Species

Homo sapiens

Ensembl Protein

ENSP00000264335

InnateDB Gene

IDBG-14629 (YWHAE)

Protein Structure

UniProt Annotation

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Subcellular Localization

Cytoplasm {ECO:0000250}. Melanosome {ECO:0000269PubMed:12042314, ECO:0000269PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 439 experimentally validated interaction(s) in this database.
They are also associated with 142 interaction(s) predicted by orthology.

Experimentally validated
Total	439 [view]
Protein-Protein	433 [view]
Protein-DNA	5 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	142 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015459	potassium channel regulator activity
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0023026	MHC class II protein complex binding
GO:0032403	protein complex binding
GO:0042826	histone deacetylase binding
GO:0044325	ion channel binding
GO:0044822	poly(A) RNA binding
GO:0046982	protein heterodimerization activity
GO:0050815	phosphoserine binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0001764	neuron migration
GO:0003064	regulation of heart rate by hormone
GO:0006605	protein targeting
GO:0006915	apoptotic process
GO:0016032	viral process
GO:0021762	substantia nigra development
GO:0021766	hippocampus development
GO:0021987	cerebral cortex development
GO:0035308	negative regulation of protein dephosphorylation
GO:0035329	hippo signaling
GO:0035556	intracellular signal transduction
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0060306	regulation of membrane repolarization
GO:0061024	membrane organization
GO:0086013	membrane repolarization during cardiac muscle cell action potential
GO:0086091	regulation of heart rate by cardiac conduction
GO:0097190	apoptotic signaling pathway
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901016	regulation of potassium ion transmembrane transporter activity
GO:1902309	negative regulation of peptidyl-serine dephosphorylation

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005871	kinesin complex
GO:0016020	membrane
GO:0030424	axon
GO:0030659	cytoplasmic vesicle membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome