Homo sapiens Gene: YWHAE
Summary
InnateDB Gene IDBG-14629.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol YWHAE
Gene Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
Synonyms 14-3-3E; HEL2; KCIP-1; MDCR; MDS
Species Homo sapiens
Ensembl Gene ENSG00000108953
Encoded Proteins
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
YWHAE (14-3-3 epsilon) interacts with key components of mitogen-activated protein kinase (MAPK)signal module for selective modulation of the TNF-alpha-induced time course-dependent NF-kappaB activity.
Entrez Gene
Summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100%% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:1344272-1400378
Strand Reverse strand
Band p13.3
Transcripts
ENST00000264335 ENSP00000264335
ENST00000466227 ENSP00000464883
ENST00000496706 ENSP00000466324
ENST00000469398
ENST00000486241
ENST00000489287
ENST00000498643
ENST00000576854
ENST00000575977 ENSP00000460712
ENST00000571732 ENSP00000461762
ENST00000573026 ENSP00000458386
ENST00000572108
ENST00000573196 ENSP00000461766
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 439 experimentally validated interaction(s) in this database.
They are also associated with 142 interaction(s) predicted by orthology.
Experimentally validated
Total 439 [view]
Protein-Protein 433 [view]
Protein-DNA 5 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 142 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015459 potassium channel regulator activity
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0023026 MHC class II protein complex binding
GO:0032403 protein complex binding
GO:0042826 histone deacetylase binding
GO:0044325 ion channel binding
GO:0044822 poly(A) RNA binding
GO:0046982 protein heterodimerization activity
GO:0050815 phosphoserine binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0001764 neuron migration
GO:0003064 regulation of heart rate by hormone
GO:0006605 protein targeting
GO:0006915 apoptotic process
GO:0016032 viral process
GO:0021762 substantia nigra development
GO:0021766 hippocampus development
GO:0021987 cerebral cortex development
GO:0035308 negative regulation of protein dephosphorylation
GO:0035329 hippo signaling
GO:0035556 intracellular signal transduction
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0060306 regulation of membrane repolarization
GO:0061024 membrane organization
GO:0086013 membrane repolarization during cardiac muscle cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:0097190 apoptotic signaling pathway
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901016 regulation of potassium ion transmembrane transporter activity
GO:1902309 negative regulation of peptidyl-serine dephosphorylation
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005871 kinesin complex
GO:0016020 membrane
GO:0030424 axon
GO:0030659 cytoplasmic vesicle membrane
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
Alpha6Beta4Integrin pathway
TNFalpha pathway
Hedgehog pathway
REACTOME
Regulation of PLK1 Activity at G2/M Transition pathway
Loss of Nlp from mitotic centrosomes pathway
Loss of proteins required for interphase microtubule organization√?¬†from the centrosome pathway
Recruitment of mitotic centrosome proteins and complexes pathway
NADE modulates death signalling pathway
Signaling by Hippo pathway
Activation of BAD and translocation to mitochondria pathway
Translocation of GLUT4 to the plasma membrane pathway
Cellular responses to stress pathway
Signalling by NGF pathway
Regulation of HSF1-mediated heat shock response pathway
p75 NTR receptor-mediated signalling pathway
Apoptosis pathway
Signal Transduction pathway
Cell Cycle pathway
Activation of BH3-only proteins pathway
Centrosome maturation pathway
G2/M Transition pathway
Cellular response to heat stress pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
Cell Cycle, Mitotic pathway
Intrinsic Pathway for Apoptosis pathway
Mitotic G2-G2/M phases pathway
HSF1 activation pathway
Membrane Trafficking pathway
KEGG
Cell cycle pathway
Neurotrophin signaling pathway pathway
Oocyte meiosis pathway
INOH
Wnt signaling pathway pathway
Insulin receptor signaling pathway
Fas signaling pathway pathway
PID NCI
IGF1 pathway
p75(NTR)-mediated signaling
Signaling events mediated by HDAC Class II
TGF-beta receptor signaling
Lissencephaly gene (LIS1) in neuronal migration and development
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL I3L0W5
UniProt Splice Variant
Entrez Gene 7531
UniGene Hs.513851 Hs.591239 Hs.702447 Hs.704053
RefSeq NM_006761
HUGO HGNC:12851
OMIM 605066
CCDS CCDS11001
HPRD 05457
IMGT
EMBL AC032044
GenPept
RNA Seq Atlas 7531