InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Edf1

Summary

InnateDB Protein

IDBP-146361.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Edf1

Protein Name

endothelial differentiation-related factor 1

Synonyms

0610008L11Rik; AA409425;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015236

InnateDB Gene

IDBG-146359 (Edf1)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. Might function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, liver, kidney and heart (at protein level). Also expressed in testis. {ECO:0000269PubMed:11587857}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0043565	sequence-specific DNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0030154	cell differentiation
GO:0043388	positive regulation of DNA binding

Cellular Component

GO:0005634	nucleus
GO:0005669	transcription factor TFIID complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1891227

InterPro

IPR001387 Cro/C1-type helix-turn-helix domain
IPR010982 Lambda repressor-like, DNA-binding domain
IPR013729 Multiprotein bridging factor 1, N-terminal

PFAM

PF01381
PF13443
PF13413
PF08523

PRINTS

PIRSF

SMART

SM00530

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JMG1