InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wisp1

Summary

InnateDB Protein

IDBP-146805.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wisp1

Protein Name

WNT1 inducible signaling pathway protein 1

Synonyms

AW146261; CCN4; Elm1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005255

InnateDB Gene

IDBG-146803 (Wisp1)

Protein Structure

UniProt Annotation

Function

Downstream regulator in the Wnt/Frizzled-signaling pathway (By similarity). Associated with cell survival. Adheres to skin and melanoma fibroblasts (By similarity). In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan (By similarity). Suppresses tumor growth in vivo. {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in kidney and lung. Lower levels in heart, brain, spleen, liver, skeletal muscle and testis. Expressed in low metastatic melanoma cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding

Biological Process

GO:0001558	regulation of cell growth
GO:0007155	cell adhesion
GO:0016055	Wnt signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1197008

InterPro

IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR000884 Thrombospondin, type 1 repeat
IPR001007 von Willebrand factor, type C
IPR006207 Cystine knot, C-terminal
IPR006208 Glycoprotein hormone subunit beta, cystine knot
IPR012395 IGFBP-related, CNN

PFAM

PF00219
PF00090
PF00093
PF00007

PRINTS

PIRSF

PIRSF036495

SMART

SM00121
SM00209
SM00214
SM00041

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt