InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ndrg1

Summary

InnateDB Protein

IDBP-146855.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndrg1

Protein Name

N-myc downstream regulated gene 1

Synonyms

CAP43; CMT4D; DRG1; HMSNL; Ndr1; Ndrl; NMSL; PROXY1; RTP; TDD5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005256

InnateDB Gene

IDBG-146853 (Ndrg1)

Protein Structure

UniProt Annotation

Function

Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- mediated caspase activation and apoptosis. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy (By similarity). Has a role in cell trafficking notably of the Schwann cell and is necessary for the maintenance and development of the peripheral nerve myelin sheath. {ECO:0000250, ECO:0000269PubMed:15082788, ECO:0000269PubMed:21303696}.

Subcellular Localization

Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cell membrane {ECO:0000250}. Note=Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and with the plasma membrane (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed, with highest levels in kidney followed by brain, pancreas, small intestine, colon and spleen (at protein level). Also detected in heart and preputial gland, and in much smaller quantities in other tissues. Not detected in duodenum and prostate. Highly expressed in Schwann cells. {ECO:0000269PubMed:15082788, ECO:0000269PubMed:15461589, ECO:0000269PubMed:21636852, ECO:0000269PubMed:9144177}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 73 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	73 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0017137	Rab GTPase binding
GO:0043015	gamma-tubulin binding
GO:0045296	cadherin binding

Biological Process

GO:0030330	DNA damage response, signal transduction by p53 class mediator
GO:0032287	peripheral nervous system myelin maintenance
GO:0045576	mast cell activation
GO:0071456	cellular response to hypoxia
GO:0090232	positive regulation of spindle checkpoint

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0005913	cell-cell adherens junction
GO:0015630	microtubule cytoskeleton
GO:0048471	perinuclear region of cytoplasm
GO:0055038	recycling endosome membrane
GO:0070062	extracellular vesicular exosome