Version 5.4
Homo sapiens Protein: ACRBP
Summary
InnateDB Protein IDBP-14698.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACRBP
Protein Name acrosin binding protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000229243
InnateDB Gene IDBG-14696 (ACRBP)
Protein Structure
UniProt Annotation
Function May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin. {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}. Note=Colocalizes with proacrosin in the acrosome of sperm. {ECO:0000250}.
Disease Associations
Tissue Specificity Expression restricted to testis in normal tissue. Expressed in a wide spectrum of cancers, including bladder, breast, liver, lung and colon cancers. {ECO:0000269PubMed:11248070}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005576 extracellular region
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR009865 Proacrosin binding sp32
PFAM PF07222
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NEB7
PhosphoSite PhosphoSite-Q8NEB7
TrEMBL
UniProt Splice Variant
Entrez Gene 84519
UniGene Hs.123239
RefSeq NP_115878
HUGO HGNC:17195
OMIM 608352
CCDS CCDS8554
HPRD 16322
IMGT
EMBL AB051833 BC033010
GenPept AAH33010 BAB39388

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca