InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: COMT

Summary

InnateDB Protein

IDBP-1474.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COMT

Protein Name

catechol-O-methyltransferase

Synonyms

HEL-S-98n;

Species

Homo sapiens

Ensembl Protein

ENSP00000354511

InnateDB Gene

IDBG-1506 (COMT)

Protein Structure

UniProt Annotation

Function

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

Subcellular Localization

Isoform Soluble: Cytoplasm.Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side.

Disease Associations

Tissue Specificity

Brain, liver, placenta, lymphocytes and erythrocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0008171	O-methyltransferase activity
GO:0016206	catechol O-methyltransferase activity

Biological Process

GO:0006584	catecholamine metabolic process
GO:0006805	xenobiotic metabolic process
GO:0007268	synaptic transmission
GO:0007565	female pregnancy
GO:0007612	learning
GO:0007614	short-term memory
GO:0008210	estrogen metabolic process
GO:0009712	catechol-containing compound metabolic process
GO:0014070	response to organic cyclic compound
GO:0016036	cellular response to phosphate starvation
GO:0032259	methylation
GO:0032496	response to lipopolysaccharide
GO:0032502	developmental process
GO:0035814	negative regulation of renal sodium excretion
GO:0042135	neurotransmitter catabolic process
GO:0042136	neurotransmitter biosynthetic process
GO:0042417	dopamine metabolic process
GO:0042420	dopamine catabolic process
GO:0042493	response to drug
GO:0044281	small molecule metabolic process
GO:0045963	negative regulation of dopamine metabolic process
GO:0048265	response to pain
GO:0048609	multicellular organismal reproductive process
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050668	positive regulation of homocysteine metabolic process
GO:0051930	regulation of sensory perception of pain

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0043197	dendritic spine
GO:0044297	cell body
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002935 O-methyltransferase, family 3
IPR017128 Catechol O-methyltransferase, eukaryotic
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF01596

PRINTS

PIRSF

PIRSF037177

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P21964