Homo sapiens Gene: COMT
Summary
InnateDB Gene IDBG-1506.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COMT
Gene Name catechol-O-methyltransferase
Synonyms HEL-S-98n;
Species Homo sapiens
Ensembl Gene ENSG00000093010
Encoded Proteins
catechol-O-methyltransferase
catechol-O-methyltransferase
catechol-O-methyltransferase
catechol-O-methyltransferase
catechol-O-methyltransferase
catechol-O-methyltransferase
catechol-O-methyltransferase
catechol-O-methyltransferase
catechol-O-methyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:19941607-19969975
Strand Forward strand
Band q11.21
Transcripts
ENST00000361682 ENSP00000354511
ENST00000207636 ENSP00000207636
ENST00000403710 ENSP00000385917
ENST00000407537 ENSP00000384654
ENST00000406520 ENSP00000385150
ENST00000403184 ENSP00000383966
ENST00000412786 ENSP00000403958
ENST00000449653 ENSP00000416778
ENST00000428707 ENSP00000387695
ENST00000467943
ENST00000493893
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0008171 O-methyltransferase activity
GO:0016206 catechol O-methyltransferase activity
Biological Process
GO:0006584 catecholamine metabolic process
GO:0006805 xenobiotic metabolic process
GO:0007268 synaptic transmission
GO:0007565 female pregnancy
GO:0007612 learning
GO:0007614 short-term memory
GO:0008210 estrogen metabolic process
GO:0009712 catechol-containing compound metabolic process
GO:0014070 response to organic cyclic compound
GO:0016036 cellular response to phosphate starvation
GO:0032259 methylation
GO:0032496 response to lipopolysaccharide
GO:0032502 developmental process
GO:0035814 negative regulation of renal sodium excretion
GO:0042135 neurotransmitter catabolic process
GO:0042136 neurotransmitter biosynthetic process
GO:0042417 dopamine metabolic process
GO:0042420 dopamine catabolic process
GO:0042493 response to drug
GO:0044281 small molecule metabolic process
GO:0045963 negative regulation of dopamine metabolic process
GO:0048265 response to pain
GO:0048609 multicellular organismal reproductive process
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050668 positive regulation of homocysteine metabolic process
GO:0051930 regulation of sensory perception of pain
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0043197 dendritic spine
GO:0044297 cell body
GO:0045211 postsynaptic membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Methylation pathway
Neuronal System pathway
Dopamine clearance from the synaptic cleft pathway
Enzymatic degradation of Dopamine by monoamine oxidase pathway
Enzymatic degradation of dopamine by COMT pathway
Neurotransmitter Clearance In The Synaptic Cleft pathway
Phase II conjugation pathway
Transmission across Chemical Synapses pathway
Metabolism pathway
Biological oxidations pathway
KEGG
Steroid hormone biosynthesis pathway
Tyrosine metabolism pathway
INOH
Tyrosine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P21964
TrEMBL F2WW53
UniProt Splice Variant
Entrez Gene 1312
UniGene Hs.370408
RefSeq NM_007310 NM_000754 NM_001135161 NM_001135162 XM_005261229
HUGO HGNC:2228
OMIM 116790
CCDS CCDS46663 CCDS13770
HPRD 00284
IMGT
EMBL AC000080 AC000090 AC005663 AK290440 AY341246 BC011935 BC100018 CH471176 CR456422 CR456997 HQ262572 HQ262573 M58525 M65212 M65213 Z26491
GenPept AAA68927 AAA68928 AAA68929 AAH11935 AAI00019 AAP88929 AEA30239 AEA30240 BAF83129 CAA81263 CAG30308 CAG33278 EAX03010
RNA Seq Atlas 1312