InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: COMT

Summary

InnateDB Gene

IDBG-1506.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COMT

Gene Name

catechol-O-methyltransferase

Synonyms

HEL-S-98n

Species

Homo sapiens

Ensembl Gene

ENSG00000093010

Encoded Proteins

IDBP-1474

catechol-O-methyltransferase

IDBP-1508

catechol-O-methyltransferase

IDBP-292530

catechol-O-methyltransferase

IDBP-292531

catechol-O-methyltransferase

IDBP-292532

catechol-O-methyltransferase

IDBP-292533

catechol-O-methyltransferase

IDBP-362332

catechol-O-methyltransferase

IDBP-362337

catechol-O-methyltransferase

IDBP-362339

catechol-O-methyltransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:19941607-19969975

Strand

Forward strand

Band

q11.21

Transcripts

ENST00000361682	ENSP00000354511
ENST00000207636	ENSP00000207636
ENST00000403710	ENSP00000385917
ENST00000407537	ENSP00000384654
ENST00000406520	ENSP00000385150
ENST00000403184	ENSP00000383966
ENST00000412786	ENSP00000403958
ENST00000449653	ENSP00000416778
ENST00000428707	ENSP00000387695
ENST00000467943
ENST00000493893

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0008171	O-methyltransferase activity
GO:0016206	catechol O-methyltransferase activity

Biological Process

GO:0006584	catecholamine metabolic process
GO:0006805	xenobiotic metabolic process
GO:0007268	synaptic transmission
GO:0007565	female pregnancy
GO:0007612	learning
GO:0007614	short-term memory
GO:0008210	estrogen metabolic process
GO:0009712	catechol-containing compound metabolic process
GO:0014070	response to organic cyclic compound
GO:0016036	cellular response to phosphate starvation
GO:0032259	methylation
GO:0032496	response to lipopolysaccharide
GO:0032502	developmental process
GO:0035814	negative regulation of renal sodium excretion
GO:0042135	neurotransmitter catabolic process
GO:0042136	neurotransmitter biosynthetic process
GO:0042417	dopamine metabolic process
GO:0042420	dopamine catabolic process
GO:0042493	response to drug
GO:0044281	small molecule metabolic process
GO:0045963	negative regulation of dopamine metabolic process
GO:0048265	response to pain
GO:0048609	multicellular organismal reproductive process
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050668	positive regulation of homocysteine metabolic process
GO:0051930	regulation of sensory perception of pain

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0043197	dendritic spine
GO:0044297	cell body
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome