InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abca1

Summary

InnateDB Protein

IDBP-147644.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abca1

Protein Name

ATP-binding cassette, sub-family A (ABC1), member 1

Synonyms

ABC-1; Abc1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030010

InnateDB Gene

IDBG-147642 (Abca1)

Protein Structure

UniProt Annotation

Function

cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed in adult tissues. Highest levels are found in pregnant uterus and uterus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	3 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005548	phospholipid transporter activity
GO:0008509	anion transmembrane transporter activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0017127	cholesterol transporter activity
GO:0019905	syntaxin binding
GO:0031267	small GTPase binding
GO:0034185	apolipoprotein binding
GO:0034186	apolipoprotein A-I binding
GO:0034188	apolipoprotein A-I receptor activity
GO:0051117	ATPase binding

Biological Process

GO:0002790	peptide secretion
GO:0006200	ATP catabolic process
GO:0006497	protein lipidation
GO:0006911	phagocytosis, engulfment
GO:0007040	lysosome organization
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007584	response to nutrient
GO:0008203	cholesterol metabolic process
GO:0010875	positive regulation of cholesterol efflux
GO:0015914	phospholipid transport
GO:0016197	endosomal transport
GO:0030301	cholesterol transport
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0032367	intracellular cholesterol transport
GO:0032489	regulation of Cdc42 protein signal transduction
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034380	high-density lipoprotein particle assembly
GO:0034616	response to laminar fluid shear stress
GO:0038027	apolipoprotein A-I-mediated signaling pathway
GO:0042157	lipoprotein metabolic process
GO:0042158	lipoprotein biosynthetic process
GO:0042493	response to drug
GO:0042632	cholesterol homeostasis
GO:0043691	reverse cholesterol transport
GO:0045087	innate immune response (InnateDB)
GO:0045332	phospholipid translocation
GO:0050702	interleukin-1 beta secretion
GO:0055091	phospholipid homeostasis
GO:0055098	response to low-density lipoprotein particle stimulus
GO:0060155	platelet dense granule organization
GO:0071222	cellular response to lipopolysaccharide
GO:0071300	cellular response to retinoic acid
GO:0071397	cellular response to cholesterol

Cellular Component

GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0030139	endocytic vesicle
GO:0034364	high-density lipoprotein particle
GO:0043231	intracellular membrane-bounded organelle
GO:0045121	membrane raft
GO:0045335	phagocytic vesicle
GO:0048471	perinuclear region of cytoplasm