InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Senp2

Summary

InnateDB Protein

IDBP-147703.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Senp2

Protein Name

SUMO/sentrin specific peptidase 2

Synonyms

2310007L05Rik; 4930538C18Rik; AI646780; AW554757; mKIAA1331; Smt3ip2; SuPr-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023561

InnateDB Gene

IDBG-147701 (Senp2)

Protein Structure

UniProt Annotation

Function

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1 (By similarity). Isoform 3 activates transcription. {ECO:0000250, ECO:0000269PubMed:11489887, ECO:0000269PubMed:12419228}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12419228}.Isoform 1: Nucleus, nuclear pore complex. Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Nucleoplasmic side {ECO:0000250}.Isoform 2: Cytoplasm. Cytoplasmic vesicle. Note=Found in the cytoplasm and in cytoplasmic vesicles, together with axin.Isoform 3: Nucleus, PML body.

Disease Associations

Tissue Specificity

Highly expressed in testis. Detected in brain, heart and thymus. {ECO:0000269PubMed:12419228}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0016929	SUMO-specific protease activity
GO:0019904	protein domain specific binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006351	transcription, DNA-templated
GO:0006508	proteolysis
GO:0007507	heart development
GO:0009950	dorsal/ventral axis specification
GO:0015031	protein transport
GO:0016055	Wnt signaling pathway
GO:0016926	protein desumoylation
GO:0032091	negative regulation of protein binding
GO:0032875	regulation of DNA endoreduplication
GO:0035562	negative regulation of chromatin binding
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051028	mRNA transport
GO:0051246	regulation of protein metabolic process
GO:0060707	trophoblast giant cell differentiation
GO:0060711	labyrinthine layer development
GO:0060712	spongiotrophoblast layer development
GO:1901797	negative regulation of signal transduction by p53 class mediator
GO:2000045	regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005737	cytoplasm
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0016604	nuclear body
GO:0016605	PML body
GO:0031410	cytoplasmic vesicle
GO:0031965	nuclear membrane