InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lmnb1

Summary

InnateDB Protein

IDBP-147939.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lmnb1

Protein Name

lamin B1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025486

InnateDB Gene

IDBG-147937 (Lmnb1)

Protein Structure

UniProt Annotation

Function

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.

Subcellular Localization

Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0008432	JUN kinase binding
GO:0043274	phospholipase binding

Biological Process

GO:0031662	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle
GO:0046330	positive regulation of JNK cascade

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005637	nuclear inner membrane
GO:0005638	lamin filament
GO:0005654	nucleoplasm
GO:0005882	intermediate filament
GO:0016020	membrane
GO:0031965	nuclear membrane