InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lmnb1

Summary

InnateDB Gene

IDBG-147937.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lmnb1

Gene Name

lamin B1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024590

Encoded Proteins

IDBP-147939

lamin B1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113368:
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:56707813-56753424

Strand

Forward strand

Band

Transcripts

ENSMUST00000025486	ENSMUSP00000025486
ENSMUST00000128651

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0008432	JUN kinase binding
GO:0043274	phospholipase binding

Biological Process

GO:0031662	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle
GO:0046330	positive regulation of JNK cascade

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005637	nuclear inner membrane
GO:0005638	lamin filament
GO:0005654	nucleoplasm
GO:0005882	intermediate filament
GO:0016020	membrane
GO:0031965	nuclear membrane