Mus musculus Gene: Lmnb1
Summary
InnateDB Gene IDBG-147937.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lmnb1
Gene Name lamin B1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000024590
Encoded Proteins
lamin B1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113368:
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:56707813-56753424
Strand Forward strand
Band D3
Transcripts
ENSMUST00000025486 ENSMUSP00000025486
ENSMUST00000128651
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0008432 JUN kinase binding
GO:0043274 phospholipase binding
Biological Process
GO:0031662 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle
GO:0046330 positive regulation of JNK cascade
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0005638 lamin filament
GO:0005654 nucleoplasm
GO:0005882 intermediate filament
GO:0016020 membrane
GO:0031965 nuclear membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Apoptosis pathway
Mus musculus biological processes pathway
Breakdown of the nuclear lamina pathway
Cellular responses to stress pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Apoptotic cleavage of cellular proteins pathway
Meiotic synapsis pathway
Cell Cycle pathway
Cellular Senescence pathway
Meiotic Synapsis pathway
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
Meiosis pathway
Apoptotic execution phase pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TSLP pathway
REACTOME
Apoptotic execution phase pathway
Cellular responses to stress pathway
Initiation of Nuclear Envelope Reformation pathway
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
Meiotic synapsis pathway
Apoptosis pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Apoptotic cleavage of cellular proteins pathway
M Phase pathway
Cellular Senescence pathway
Mitotic Anaphase pathway
Mitotic Prophase pathway
Nuclear Envelope Reassembly pathway
Breakdown of the nuclear lamina pathway
Cell Cycle, Mitotic pathway
Meiosis pathway
Depolymerisation of the Nuclear Lamina pathway
Nuclear Envelope Breakdown pathway
Clearance of Nuclear Envelope Membranes from Chromatin pathway
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID BIOCARTA
Tnfr1 signaling pathway [Biocarta view]
Hiv-1 nef: negative effector of fas and tnf [Biocarta view]
Caspase cascade in apoptosis [Biocarta view]
PID NCI
Cross-References
SwissProt P14733
TrEMBL
UniProt Splice Variant
Entrez Gene 16906
UniGene Mm.4105 Mm.457704
RefSeq NM_010721 XM_006525693
OMIM
CCDS CCDS29261
HPRD
IMGT
MGI ID MGI:96795
MGI Symbol Lmnb1
EMBL BC052729 BC058392 D50080 M35153 X16705
GenPept AAC96023 AAH52729 AAH58392 BAA08784 CAA34677
RNA Seq Atlas 16906