InnateDB Protein
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IDBP-147993.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mme
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Protein Name
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membrane metallo endopeptidase
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Synonyms
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6030454K05Rik; C85356; CALLA; CD10; NEP; SFE;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000029400
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InnateDB Gene
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IDBG-147991 (Mme)
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Protein Structure
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Function |
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (By similarity). Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. {ECO:0000250, ECO:0000269PubMed:20876573}.
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Subcellular Localization |
Cell membrane; Single-pass type II membrane protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
69 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:97004
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InterPro |
IPR008753
Peptidase M13, N-terminal domain
IPR018497
Peptidase M13, C-terminal domain
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PFAM |
PF05649
PF01431
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PRINTS |
PR00786
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q61391
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PhosphoSite |
PhosphoSite-Q61391
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TrEMBL |
Q8BNU9
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UniProt Splice Variant |
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Entrez Gene |
17380
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UniGene |
Mm.422356
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RefSeq |
NP_032630
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MGI ID |
2YVC
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MGI Symbol |
Mme
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OMIM |
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CCDS |
CCDS17381
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HPRD |
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IMGT |
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EMBL |
AK031446
AK033824
AK080202
BC034092
BC066840
M81591
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GenPept |
AAA37386
AAH34092
AAH66840
BAC27410
BAC28487
BAC37847
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