Mus musculus Protein: Plch1 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-148216.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | Plch1 | ||||||||||||||
Protein Name | phospholipase C, eta 1 | ||||||||||||||
Synonyms | |||||||||||||||
Species | Mus musculus | ||||||||||||||
Ensembl Protein | ENSMUSP00000081122 | ||||||||||||||
InnateDB Gene | IDBG-148210 (Plch1) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269PubMed:15702972}. | ||||||||||||||
Subcellular Localization | Cytoplasm. Membrane {ECO:0000250}. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | Expressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and spinal cord. {ECO:0000269PubMed:15702972}. | ||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | MGI:2683547 | ||||||||||||||
InterPro |
IPR000008
C2 domain IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain IPR001192 Phosphoinositide phospholipase C family IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain IPR001849 Pleckstrin homology domain IPR002048 EF-hand domain IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain |
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PFAM |
PF00168
PF00388 PF00387 PF00169 PF00036 PF13202 PF13405 PF09279 |
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PRINTS |
PR00360
PR00390 |
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PIRSF | |||||||||||||||
SMART |
SM00239
SM00148 SM00149 SM00233 SM00054 |
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TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q4KWH5 | ||||||||||||||
PhosphoSite | PhosphoSite-Q4KWH5 | ||||||||||||||
TrEMBL | Q6PFD8 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 269437 | ||||||||||||||
UniGene | Mm.488521 | ||||||||||||||
RefSeq | NP_899014 | ||||||||||||||
MGI ID | |||||||||||||||
MGI Symbol | Plch1 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | CCDS38444 | ||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | AK173095 AY691172 AY691173 AY691174 BC042549 BC052372 BC055005 BC057610 | ||||||||||||||
GenPept | AAH42549 AAH52372 AAH55005 AAH57610 AAW22609 AAW22610 AAW22611 BAD32373 | ||||||||||||||