Version 5.4
Mus musculus Gene: Plch1
Summary
InnateDB Gene IDBG-148210.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plch1
Gene Name phospholipase C, eta 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000036834
Encoded Proteins
IDBP-148212
phospholipase C, eta 1
IDBP-148214
phospholipase C, eta 1
IDBP-148216
phospholipase C, eta 1
IDBP-533117
phospholipase C, eta 1
IDBP-536090
phospholipase C, eta 1
IDBP-534674
phospholipase C, eta 1
IDBP-534608
phospholipase C, eta 1
IDBP-541365
phospholipase C, eta 1
IDBP-715862
IDBP-717213
IDBP-716900
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114805:
PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]).[supplied by OMIM, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:63696234-63899472
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000048134 ENSMUSP00000047693
ENSMUST00000059973 ENSMUSP00000058524
ENSMUST00000084105 ENSMUSP00000081122
ENSMUST00000162269 ENSMUSP00000124463
ENSMUST00000160638 ENSMUSP00000123921
ENSMUST00000159982
ENSMUST00000159374
ENSMUST00000159676 ENSMUSP00000124632
ENSMUST00000161052 ENSMUSP00000125581
ENSMUST00000159188 ENSMUSP00000124491
ENSMUST00000175947 ENSMUSP00000135353
ENSMUST00000177143 ENSMUSP00000135424
ENSMUST00000176861 ENSMUSP00000135562
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
GO:0050429 calcium-dependent phospholipase C activity
Biological Process
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0008152 metabolic process
GO:0016042 lipid catabolic process
GO:0035556 intracellular signal transduction
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0031965 nuclear membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000114805
View Gene Order
ENSBTAG00000008307
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_196476
Inositol phosphate metabolism pathway
REACT_196473
Synthesis of IP3 and IP4 in the cytosol pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150312
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.316391 Mm.413368 Mm.488521
RefSeq NM_001177732 NM_001177733 NM_183191 XM_006501530 XM_006501531 XM_006501532 XM_006501533 XM_006501534 XM_006501535 XM_006501536 XM_006501537 XM_006501538 XM_006501540
OMIM
CCDS CCDS38444 CCDS50918 CCDS57215
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca