InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il18rap

Summary

InnateDB Protein

IDBP-148674.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il18rap

Protein Name

interleukin 18 receptor accessory protein

Synonyms

AcPL; IL-18R-beta; IL-18RAcP; IL-18Rbeta; IL-1RAcPL;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027237

InnateDB Gene

IDBG-148672 (Il18rap)

Protein Structure

UniProt Annotation

Function

Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. Together with IL18R1 mediates IL- 18-dependent activation of NF-kappa-B and JNK. {ECO:0000269PubMed:11046021, ECO:0000269PubMed:15843532, ECO:0000269PubMed:9792649}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004908	interleukin-1 receptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0019221	cytokine-mediated signaling pathway

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1338888

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR003599 Immunoglobulin subtype
IPR004074 Interleukin-1 receptor type I/II
IPR007110 Immunoglobulin-like domain

PFAM

PF01582
PF13676

PRINTS

PR01536

PIRSF

SMART

SM00255
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt