InnateDB Protein
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IDBP-149637.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Snrpd2
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Protein Name
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small nuclear ribonucleoprotein D2
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Synonyms
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1810009A06Rik; SMD2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000037597
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InnateDB Gene
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IDBG-149635 (Snrpd2)
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Protein Structure
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Function |
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
78 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:98345
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InterPro |
IPR001163
Ribonucleoprotein LSM domain
IPR006649
Ribonucleoprotein LSM domain, eukaryotic/archaea-type
IPR010920
Like-Sm (LSM) domain
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PFAM |
PF01423
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PRINTS |
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PIRSF |
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SMART |
SM00651
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TIGRFAMs |
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Modification |
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SwissProt |
P62317
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PhosphoSite |
PhosphoSite-P62317
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TrEMBL |
Q14AF6
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UniProt Splice Variant |
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Entrez Gene |
545531
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UniGene |
Mm.357757
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RefSeq |
NP_081219
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MGI ID |
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MGI Symbol |
Snrpd2
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OMIM |
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CCDS |
CCDS20892
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HPRD |
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IMGT |
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EMBL |
AK007389
AK045968
AK088105
BC043014
BC051208
BC116858
BC116860
CH466639
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GenPept |
AAH43014
AAH51208
AAI16859
AAI16861
BAB25006
BAC32551
BAC40147
EDL23112
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