Version 5.4
Mus musculus Protein: Ldb3
Summary
InnateDB Protein IDBP-149842.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ldb3
Protein Name LIM domain binding 3
Synonyms AW742271; PDLIM6; ZASP;
Species Mus musculus
Ensembl Protein ENSMUSP00000022330
InnateDB Gene IDBG-149830 (Ldb3)
Protein Structure
UniProt Annotation
Function May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. {ECO:0000303PubMed:10391924}.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000269PubMed:10391924}. Cell projection, pseudopodium {ECO:0000269PubMed:10391924}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:10391924}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269PubMed:10391924}. Note=Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2 at the Z-lines.
Disease Associations
Tissue Specificity Expressed primarily in adult heart and skeletal muscle, and detected at lower levels in lung. Isoforms are expressed in a tissue-specific manner. Isoform 1, isoform 3 and isoform 5 are expressed in heart, whereas isoform 2, isoform 4 and isoform 6 are expressed in skeletal muscle. {ECO:0000269PubMed:10391924, ECO:0000269PubMed:10427098, ECO:0000269PubMed:10727866, ECO:0000269PubMed:12499364}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0051371 muscle alpha-actinin binding
Biological Process
GO:0045214 sarcomere organization
Cellular Component
GO:0005856 cytoskeleton
GO:0030018 Z disc
GO:0031143 pseudopodium
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:1344412
InterPro IPR001478 PDZ domain
IPR006643 ZASP
PFAM PF00595
PF13180
PRINTS
PIRSF
SMART SM00228
SM00735
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JKS4
PhosphoSite PhosphoSite-Q9JKS4
TrEMBL
UniProt Splice Variant
Entrez Gene 24131
UniGene Mm.29733
RefSeq NP_001034165
MGI ID 1WJL
MGI Symbol Ldb3
OMIM
CCDS CCDS26942
HPRD
IMGT
EMBL AF114378 AF114379 AF228057 AF228058 AJ005621 AK004020 AK137181 AK142292 AK172980 AY206011 AY206012 AY206013 AY206015 BC099596 BC138793 BC145420
GenPept AAD42950 AAD42951 AAF33847 AAF33848 AAH99596 AAI38794 AAI45421 AAO26187 AAO26188 AAO26189 AAO26190 BAB23128 BAD32258 BAE23262 BAE25016 CAB46747

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca