Mus musculus Gene: Ldb3
Summary
InnateDB Gene IDBG-149830.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ldb3
Gene Name LIM domain binding 3
Synonyms AW742271; PDLIM6; ZASP;
Species Mus musculus
Ensembl Gene ENSMUSG00000021798
Encoded Proteins
LIM domain binding 3
LIM domain binding 3
LIM domain binding 3
LIM domain binding 3
LIM domain binding 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122367:
This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:34526699-34588681
Strand Reverse strand
Band B
Transcripts
ENSMUST00000022327 ENSMUSP00000022327
ENSMUST00000090040 ENSMUSP00000087494
ENSMUST00000064098 ENSMUSP00000066784
ENSMUST00000022328 ENSMUSP00000022328
ENSMUST00000022330 ENSMUSP00000022330
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0008270 zinc ion binding
GO:0051371 muscle alpha-actinin binding
Biological Process
GO:0045214 sarcomere organization
Cellular Component
GO:0005856 cytoskeleton
GO:0030018 Z disc
GO:0031143 pseudopodium
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.29733
RefSeq NM_001039071 NM_001039072 NM_001039073 NM_001039074 NM_001039076 NM_011918 XM_006519017
OMIM
CCDS CCDS26940 CCDS26941 CCDS26942 CCDS36878 CCDS36879
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas