InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gnaq

Summary

InnateDB Protein

IDBP-149875.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gnaq

Protein Name

guanine nucleotide binding protein, alpha q polypeptide

Synonyms

1110005L02Rik; 6230401I02Rik; AA408290; AW060788; Dsk1; Dsk10; Galphaq; Gq; GqI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025541

InnateDB Gene

IDBG-149873 (Gnaq)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro). {ECO:0000269PubMed:17938235, ECO:0000269PubMed:20624888}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:18802028}. Membrane {ECO:0000269PubMed:18802028}. Nucleus membrane {ECO:0000269PubMed:18802028}. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0046872	metal ion binding

Biological Process

GO:0001501	skeletal system development
GO:0001508	action potential
GO:0006184	GTP catabolic process
GO:0006469	negative regulation of protein kinase activity
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007215	glutamate receptor signaling pathway
GO:0007507	heart development
GO:0009791	post-embryonic development
GO:0016322	neuron remodeling
GO:0021884	forebrain neuron development
GO:0035412	regulation of catenin import into nucleus
GO:0042711	maternal behavior
GO:0042733	embryonic digit morphogenesis
GO:0043547	positive regulation of GTPase activity
GO:0045634	regulation of melanocyte differentiation
GO:0048066	developmental pigmentation
GO:0050821	protein stabilization
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway

Cellular Component

GO:0005765	lysosomal membrane
GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0031965	nuclear membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:95776

InterPro

IPR000654 G-protein alpha subunit, group Q
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR002975 Fungal G-protein, alpha subunit
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR011025 G protein alpha subunit, helical insertion
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00503
PF00025

PRINTS

PR00442
PR00318
PR01241
PR00328

PIRSF

SMART

SM00275

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt