InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LAG3

Summary

InnateDB Protein

IDBP-14996.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAG3

Protein Name

lymphocyte-activation gene 3

Synonyms

CD223;

Species

Homo sapiens

Ensembl Protein

ENSP00000203629

InnateDB Gene

IDBG-14994 (LAG3)

Protein Structure

UniProt Annotation

Function

Involved in lymphocyte activation. Binds to HLA class-II antigens.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

On cell surface of activated NK and T- lymphocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003823	antigen binding
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0042289	MHC class II protein binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0045085	negative regulation of interleukin-2 biosynthetic process
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0050868	negative regulation of T cell activation