Version 5.4
Homo sapiens Gene: LAG3
Summary
InnateDB Gene IDBG-14994.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LAG3
Gene Name lymphocyte-activation gene 3
Synonyms CD223
Species Homo sapiens
Ensembl Gene ENSG00000089692
Encoded Proteins
IDBP-14996
lymphocyte-activation gene 3
IDBP-364529
lymphocyte-activation gene 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:6772512-6778455
Strand Forward strand
Band p13.31
Transcripts
ENST00000203629 ENSP00000203629
ENST00000441671 ENSP00000413825
ENST00000538079
ENST00000541049
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003823 antigen binding
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0042289 MHC class II protein binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0045085 negative regulation of interleukin-2 biosynthetic process
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0050868 negative regulation of T cell activation
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030124
View Gene Order
ENSBTAG00000034295
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.409523
RefSeq NM_002286
HUGO
OMIM
CCDS CCDS8561
HPRD 01077
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca