InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Txn1

Summary

InnateDB Protein

IDBP-149999.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Txn1

Protein Name

thioredoxin 1

Synonyms

ADF; AW550880; Trx1; Txn;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030051

InnateDB Gene

IDBG-149997 (Txn1)

Protein Structure

UniProt Annotation

Function

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity). {ECO:0000250}.ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}. Note=Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	67 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015035	protein disulfide oxidoreductase activity
GO:0015037	peptide disulfide oxidoreductase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006662	glycerol ether metabolic process
GO:0007067	mitotic nuclear division
GO:0009314	response to radiation
GO:0033158	regulation of protein import into nucleus, translocation
GO:0043388	positive regulation of DNA binding
GO:0045454	cell redox homeostasis
GO:0046826	negative regulation of protein export from nucleus
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome