InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Txn1

Summary

InnateDB Gene

IDBG-149997.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Txn1

Gene Name

thioredoxin 1

Synonyms

ADF; AW550880; Trx1; Txn

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028367

Encoded Proteins

IDBP-149999

thioredoxin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136810:
The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:57943373-57956411

Strand

Reverse strand

Band

Transcripts

ENSMUST00000030051

ENSMUSP00000030051

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	67 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015035	protein disulfide oxidoreductase activity
GO:0015037	peptide disulfide oxidoreductase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006662	glycerol ether metabolic process
GO:0007067	mitotic nuclear division
GO:0009314	response to radiation
GO:0033158	regulation of protein import into nucleus, translocation
GO:0043388	positive regulation of DNA binding
GO:0045454	cell redox homeostasis
GO:0046826	negative regulation of protein export from nucleus
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome