InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cldn1

Summary

InnateDB Protein

IDBP-150375.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cldn1

Protein Name

claudin 1

Synonyms

AI596271;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023154

InnateDB Gene

IDBG-150373 (Cldn1)

Protein Structure

UniProt Annotation

Function

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions. {ECO:0000269PubMed:10508613, ECO:0000269PubMed:11889141, ECO:0000269PubMed:23407391}.

Subcellular Localization

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Detected in epidermis and liver (at protein level). Widely expressed, with highest levels in liver and kidney. {ECO:0000269PubMed:11889141, ECO:0000269PubMed:9647647}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0016338	calcium-independent cell-cell adhesion
GO:0045216	cell-cell junction organization
GO:0061436	establishment of skin barrier

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005923	tight junction
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016328	lateral plasma membrane
GO:0030054	cell junction

Protein Structure and Domains

PDB ID

MGI:1276109

InterPro

IPR003548 Claudin-1
IPR003556 Claudin-14
IPR004031 PMP-22/EMP/MP20/Claudin superfamily
IPR006187 Claudin
IPR009571 Actin cortical patch SUR7/pH-response regulator PalI

PFAM

PF00822
PF13903
PF06687

PRINTS

PR01377
PR01077

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O88551