InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ercc2

Summary

InnateDB Protein

IDBP-150402.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ercc2

Protein Name

excision repair cross-complementing rodent repair deficiency, complementation group 2

Synonyms

AA407812; AU020867; AW240756; CXPD; Ercc-2; XPD;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000054380

InnateDB Gene

IDBG-150400 (Ercc2)

Protein Structure

UniProt Annotation

Function

ATP-dependent 5'-3' DNA helicase, component of the core- TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm, cytoskeleton, spindle {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0004672	protein kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008026	ATP-dependent helicase activity
GO:0008094	DNA-dependent ATPase activity
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0043139	5'-3' DNA helicase activity
GO:0046872	metal ion binding
GO:0047485	protein N-terminus binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0006139	nucleobase-containing compound metabolic process
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006366	transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0006979	response to oxidative stress
GO:0007059	chromosome segregation
GO:0007568	aging
GO:0008283	cell proliferation
GO:0009411	response to UV
GO:0009650	UV protection
GO:0009791	post-embryonic development
GO:0021510	spinal cord development
GO:0022405	hair cycle process
GO:0030198	extracellular matrix organization
GO:0030282	bone mineralization
GO:0032289	central nervous system myelin formation
GO:0032508	DNA duplex unwinding
GO:0033683	nucleotide-excision repair, DNA incision
GO:0035264	multicellular organism growth
GO:0035315	hair cell differentiation
GO:0040016	embryonic cleavage
GO:0043249	erythrocyte maturation
GO:0043388	positive regulation of DNA binding
GO:0043588	skin development
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048820	hair follicle maturation
GO:0060218	hematopoietic stem cell differentiation
GO:1901990	regulation of mitotic cell cycle phase transition

Cellular Component

GO:0000439	core TFIIH complex
GO:0005634	nucleus
GO:0005675	holo TFIIH complex
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0071817	MMXD complex

Protein Structure and Domains

PDB ID

MGI:95413

InterPro

IPR001945 Xeroderma pigmentosum group D protein
IPR006554 Helicase-like, DEXD box c2 type
IPR006555 ATP-dependent helicase, C-terminal
IPR010614 DEAD2
IPR010643 Domain of unknown function DUF1227
IPR013020 DNA helicase (DNA repair), Rad3 type
IPR014013 Helicase, superfamily 1/2, ATP-binding domain, DinG/Rad3-type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF13307
PF06733
PF06777

PRINTS

PR00852

PIRSF

SMART

SM00488
SM00491

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt