Version 5.4
Mus musculus Protein: Siae
Summary
InnateDB Protein IDBP-150546.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Siae
Protein Name sialic acid acetylesterase
Synonyms LSE; Ysg2;
Species Mus musculus
Ensembl Protein ENSMUSP00000002007
InnateDB Gene IDBG-150542 (Siae)
Protein Structure
UniProt Annotation
Function Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid.
Subcellular Localization Isoform 1: Lysosome.Isoform 2: Cytoplasm.
Disease Associations
Tissue Specificity Isoform 1 is widely expressed. Isoform 2 shows a more restricted distribution with highest expression in brain and ovary and lower levels in liver and thymus.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001681 sialate O-acetylesterase activity
Biological Process
GO:0002682 regulation of immune system process
GO:0005975 carbohydrate metabolic process
GO:0008152 metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:104803
InterPro IPR005181 Domain of unknown function DUF303, acetylesterase putative
PFAM PF03629
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P70665
PhosphoSite PhosphoSite-
TrEMBL C3VDJ0
UniProt Splice Variant
Entrez Gene 22619
UniGene Mm.470448
RefSeq NP_035864
MGI ID
MGI Symbol Siae
OMIM
CCDS CCDS22983
HPRD
IMGT
EMBL AF156856 AK028598 AK028656 AK033980 AK035715 AK043392 AK164852 AK167103 BC007136 FJ859045 U40408 U61183 X98625
GenPept AAB07813 AAC52880 AAD55976 AAH07136 ACP03817 BAC26026 BAC26049 BAC28536 BAC29164 BAC31534 BAE37942 BAE39252 CAA67214

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca