Version 5.4
Mus musculus Protein: Ippk
Summary
InnateDB Protein IDBP-150800.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ippk
Protein Name inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Synonyms 1810043M15Rik; InsP6;
Species Mus musculus
Ensembl Protein ENSMUSP00000021817
InnateDB Gene IDBG-150798 (Ippk)
Protein Structure
UniProt Annotation
Function Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. {ECO:0000269PubMed:15939868}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity In brain, it is expressed throughout the hippocampus (CA1, CA2, CA3 and dentate gyrus), inner layers of the cerebral cortex, and Purkinje cells of the cerebellum. In heart, it is expressed in cardiomyocytes but not in interstitial cells, blood vessels, or valves. Also expressed in testis. {ECO:0000269PubMed:15939868}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0035299 inositol pentakisphosphate 2-kinase activity
Biological Process
GO:0052746 inositol phosphorylation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1922928
InterPro IPR009286 Inositol-pentakisphosphate 2-kinase
PFAM PF06090
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P1C1
PhosphoSite PhosphoSite-Q6P1C1
TrEMBL Q05CK0
UniProt Splice Variant
Entrez Gene 75678
UniGene Mm.390586
RefSeq NP_951011
MGI ID
MGI Symbol Ippk
OMIM
CCDS CCDS26500
HPRD
IMGT
EMBL AK029085 AK160092 AK167467 BC024630 BC062167 BC065157
GenPept AAH24630 AAH62167 AAH65157 BAE20447 BAE35623 BAE39551

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca