InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fntb

Summary

InnateDB Protein

IDBP-151395.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fntb

Protein Name

farnesyltransferase, CAAX box, beta

Synonyms

2010013E13Rik; AA409500;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035498

InnateDB Gene

IDBG-151393 (Fntb)

Protein Structure

UniProt Annotation

Function

Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C- terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X. {ECO:0000269PubMed:21520375}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004311	farnesyltranstransferase activity
GO:0004660	protein farnesyltransferase activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008270	zinc ion binding
GO:0019840	isoprenoid binding
GO:0042277	peptide binding

Biological Process

GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0010035	response to inorganic substance
GO:0014070	response to organic cyclic compound
GO:0018343	protein farnesylation
GO:0034097	response to cytokine
GO:0042060	wound healing
GO:0045787	positive regulation of cell cycle
GO:0048146	positive regulation of fibroblast proliferation
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process