Version 5.4
Mus musculus Gene: Fntb
Summary
InnateDB Gene IDBG-151393.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fntb
Gene Name farnesyltransferase, CAAX box, beta
Synonyms 2010013E13Rik; AA409500
Species Mus musculus
Ensembl Gene ENSMUSG00000033373
Encoded Proteins
IDBP-151395
farnesyltransferase, CAAX box, beta
IDBP-536292
farnesyltransferase, CAAX box, beta
IDBP-532327
farnesyltransferase, CAAX box, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125954:
This locus represents naturally occurring read-through transcription between the neighboring CHURC1 (churchill domain containing 1) and FNTB (farnesyltransferase, CAAX box, beta) on chromosome 14. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:76765589-76921412
Strand Forward strand
Band C3
Transcripts
ENSMUST00000041008 ENSMUSP00000035498
ENSMUST00000125842 ENSMUSP00000116906
ENSMUST00000137826 ENSMUSP00000120713
ENSMUST00000151864
ENSMUST00000123887
ENSMUST00000154743
ENSMUST00000136939
ENSMUST00000130605
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004311 farnesyltranstransferase activity
GO:0004660 protein farnesyltransferase activity
GO:0005515 protein binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0019840 isoprenoid binding
GO:0042277 peptide binding
Biological Process
GO:0007275 multicellular organismal development
GO:0008152 metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010035 response to inorganic substance
GO:0014070 response to organic cyclic compound
GO:0018343 protein farnesylation
GO:0034097 response to cytokine
GO:0042060 wound healing
GO:0045787 positive regulation of cell cycle
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048146 positive regulation of fibroblast proliferation
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
Cellular Component
GO:0005875 microtubule associated complex
GO:0005965 protein farnesyltransferase complex
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000125954
View Gene Order
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_188260
Visual phototransduction pathway
REACT_188266
Inactivation, recovery and regulation of the phototransduction cascade pathway
REACT_188265
The phototransduction cascade pathway
REACT_188257
Signal Transduction pathway
REACT_188255
Diseases associated with visual transduction pathway
KEGG
mmu00900
Terpenoid backbone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.151174
RefSeq NM_145927 XM_006543546
OMIM
CCDS CCDS25998
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca