InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plek

Summary

InnateDB Protein

IDBP-151615.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Plek

Protein Name

pleckstrin

Synonyms

2010300B13Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020321

InnateDB Gene

IDBG-151611 (Plek)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0042803	protein homodimerization activity
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0002576	platelet degranulation
GO:0007229	integrin-mediated signaling pathway
GO:0010920	negative regulation of inositol phosphate biosynthetic process
GO:0010925	positive regulation of inositol-polyphosphate 5-phosphatase activity
GO:0030836	positive regulation of actin filament depolymerization
GO:0030845	phospholipase C-inhibiting G-protein coupled receptor signaling pathway
GO:0030866	cortical actin cytoskeleton organization
GO:0031529	ruffle organization
GO:0031532	actin cytoskeleton reorganization
GO:0032233	positive regulation of actin filament bundle assembly
GO:0035556	intracellular signal transduction
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway
GO:0046488	phosphatidylinositol metabolic process
GO:0060305	regulation of cell diameter
GO:0070493	thrombin receptor signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0032587	ruffle membrane

Protein Structure and Domains

PDB ID

MGI:1860485

InterPro

IPR000591 DEP domain
IPR001849 Pleckstrin homology domain

PFAM

PF00610
PF00169

PRINTS

PIRSF

SMART

SM00049
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q8CAG6

UniProt Splice Variant

Entrez Gene

56193

UniGene

Mm.98232

RefSeq

MGI ID

MGI Symbol

Plek

OMIM

CCDS

HPRD

IMGT

EMBL

AK038804 AL606466

GenPept

BAC30135