InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppp3r1

Summary

InnateDB Protein

IDBP-151774.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppp3r1

Protein Name

protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)

Synonyms

CaNB1; Cnb1; MCIP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099944

InnateDB Gene

IDBG-151772 (Ppp3r1)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:20639889}. Cell membrane {ECO:0000269PubMed:20639889}. Cell membrane, sarcolemma {ECO:0000269PubMed:20639889}. Note=Translocates from the cytosol to the sarcolemma in a CIB1-dependent manner during cardiomyocytes hypertrophy.

Disease Associations

Tissue Specificity

Brain specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019899	enzyme binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0001837	epithelial to mesenchymal transition
GO:0006470	protein dephosphorylation
GO:0007507	heart development
GO:0034504	protein localization to nucleus
GO:0045087	innate immune response (InnateDB)
GO:0051531	NFAT protein import into nucleus
GO:0060487	lung epithelial cell differentiation