Mus musculus Gene: Ppp3r1
Summary
InnateDB Gene IDBG-151772.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp3r1
Gene Name protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
Synonyms CaNB1; Cnb1; MCIP1;
Species Mus musculus
Ensembl Gene ENSMUSG00000033953
Encoded Proteins
protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Ppp3r1 plays an important role in activation of peritoneal macrophages. Ppp3r1 induces Tnfsf10 (TRAIL) gene expression in peritoneal macrophages in an Itgam-dependent manner.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] PPP3R1 plays an important role in activation of peritoneal macrophages. PPP3R1 induces TNFSF10 (TRAIL) gene expression in peritoneal macrophages in an ITGAM-dependent manner. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000221823:
Gene Information
Type Protein coding
Genomic Location Chromosome 11:17159263-17200375
Strand Forward strand
Band A2
Transcripts
ENSMUST00000102880 ENSMUSP00000099944
ENSMUST00000154425
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0019899 enzyme binding
Biological Process
GO:0001569 patterning of blood vessels
GO:0001837 epithelial to mesenchymal transition
GO:0006470 protein dephosphorylation
GO:0007507 heart development
GO:0034504 protein localization to nucleus
GO:0045087 innate immune response (InnateDB)
GO:0051531 NFAT protein import into nucleus
GO:0060487 lung epithelial cell differentiation
Cellular Component
GO:0005829 cytosol
GO:0042383 sarcolemma
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Apoptosis pathway
Signaling by Wnt pathway
Signaling by GPCR pathway
DARPP-32 events pathway
beta-catenin independent WNT signaling pathway
Immune System pathway
Activation of BAD and translocation to mitochondria pathway
Fc epsilon receptor (FCERI) signaling pathway
Ca2+ pathway pathway
FCERI mediated Ca+2 mobilization pathway
Activation of BH3-only proteins pathway
Opioid Signalling pathway
Signal Transduction pathway
Intrinsic Pathway for Apoptosis pathway
KEGG
MAPK signaling pathway pathway
Calcium signaling pathway pathway
Oocyte meiosis pathway
Apoptosis pathway
Wnt signaling pathway pathway
Axon guidance pathway
VEGF signaling pathway pathway
Osteoclast differentiation pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Long-term potentiation pathway
Alzheimer's disease pathway
Amyotrophic lateral sclerosis (ALS) pathway
INOH
CD4 T cell receptor signaling pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Ca2+ pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Signaling by GPCR pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Opioid Signalling pathway
Apoptosis pathway
Signal Transduction pathway
Activation of BH3-only proteins pathway
Immune System pathway
Intrinsic Pathway for Apoptosis pathway
FCERI mediated Ca+2 mobilization pathway
DARPP-32 events pathway
Activation of BAD and translocation to mitochondria pathway
Signaling by Wnt pathway
Signaling by GPCR pathway
DARPP-32 events pathway
Activation of BH3-only proteins pathway
Immune System pathway
FCERI mediated Ca+2 mobilization pathway
Ca2+ pathway pathway
Signal Transduction pathway
beta-catenin independent WNT signaling pathway
Intrinsic Pathway for Apoptosis pathway
Activation of BAD and translocation to mitochondria pathway
Opioid Signalling pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Apoptosis pathway
KEGG
MAPK signaling pathway pathway
Calcium signaling pathway pathway
Oocyte meiosis pathway
Apoptosis pathway
Wnt signaling pathway pathway
Axon guidance pathway
VEGF signaling pathway pathway
Osteoclast differentiation pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Long-term potentiation pathway
Alzheimer's disease pathway
Amyotrophic lateral sclerosis (ALS) pathway
INOH
CD4 T cell receptor signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q63810
TrEMBL
UniProt Splice Variant
Entrez Gene 19058
UniGene Mm.401506 Mm.41840 Mm.474050
RefSeq NM_024459
OMIM
CCDS CCDS24448
HPRD
IMGT
MGI ID MGI:107172
MGI Symbol Ppp3r1
EMBL AK133403 AK145541 AK160938 AK163241 AL606466 AL713926 S43864
GenPept AAB23171 BAE21637 BAE26495 BAE36102 BAE37251 CAI51912 CAI51920
RNA Seq Atlas 19058