Version 5.4
Mus musculus Gene: Ppp3r1
Summary
InnateDB Gene IDBG-151772.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp3r1
Gene Name protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
Synonyms CaNB1; Cnb1; MCIP1
Species Mus musculus
Ensembl Gene ENSMUSG00000033953
Encoded Proteins
IDBP-151774
protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22116828
Ppp3r1 plays an important role in activation of peritoneal macrophages. Ppp3r1 induces Tnfsf10 (TRAIL) gene expression in peritoneal macrophages in an Itgam-dependent manner.
InnateDB Annotation from Orthologs
Summary
PMID 22116828
[Homo sapiens] PPP3R1 plays an important role in activation of peritoneal macrophages. PPP3R1 induces TNFSF10 (TRAIL) gene expression in peritoneal macrophages in an ITGAM-dependent manner. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000221823:
Gene Information
Type Protein coding
Genomic Location Chromosome 11:17159263-17200375
Strand Forward strand
Band A2
Transcripts
ENSMUST00000102880 ENSMUSP00000099944
ENSMUST00000154425
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0019899 enzyme binding
Biological Process
GO:0001569 patterning of blood vessels
GO:0001837 epithelial to mesenchymal transition
GO:0006470 protein dephosphorylation
GO:0007507 heart development
GO:0034504 protein localization to nucleus
GO:0045087 innate immune response (InnateDB)
GO:0051531 NFAT protein import into nucleus
GO:0060487 lung epithelial cell differentiation
Cellular Component
GO:0005829 cytosol
GO:0042383 sarcolemma
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000221823
View Gene Order
ENSBTAG00000010619
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_258521
Apoptosis pathway
REACT_214014
Signaling by Wnt pathway
REACT_254215
Signaling by GPCR pathway
REACT_203795
DARPP-32 events pathway
REACT_226355
beta-catenin independent WNT signaling pathway
REACT_230745
Immune System pathway
REACT_221775
Activation of BAD and translocation to mitochondria pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_221970
Ca2+ pathway pathway
REACT_188202
FCERI mediated Ca+2 mobilization pathway
REACT_212161
Activation of BH3-only proteins pathway
REACT_242845
Opioid Signalling pathway
REACT_188257
Signal Transduction pathway
REACT_204001
Intrinsic Pathway for Apoptosis pathway
KEGG
mmu04360
Axon guidance pathway
mmu04370
VEGF signaling pathway pathway
mmu04020
Calcium signaling pathway pathway
mmu05010
Alzheimer's disease pathway
mmu04660
T cell receptor signaling pathway pathway
mmu04310
Wnt signaling pathway pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu04010
MAPK signaling pathway pathway
mmu04720
Long-term potentiation pathway
mmu04210
Apoptosis pathway
mmu04662
B cell receptor signaling pathway pathway
mmu05014
Amyotrophic lateral sclerosis (ALS) pathway
mmu04114
Oocyte meiosis pathway
mmu04380
Osteoclast differentiation pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15334
DARPP-32 events pathway
REACT_15295
Opioid Signalling pathway
REACT_549
Activation of BAD and translocation to mitochondria pathway
REACT_172761
Ca2+ pathway pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_697
Activation of BH3-only proteins pathway
REACT_6900
Immune System pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
REACT_163834
FCERI mediated Ca+2 mobilization pathway
REACT_212636
Signaling by Wnt pathway
REACT_205369
Signaling by GPCR pathway
REACT_205490
DARPP-32 events pathway
REACT_219199
Activation of BH3-only proteins pathway
REACT_213138
Immune System pathway
REACT_216829
FCERI mediated Ca+2 mobilization pathway
REACT_209727
Ca2+ pathway pathway
REACT_214353
Signal Transduction pathway
REACT_206800
beta-catenin independent WNT signaling pathway
REACT_222195
Intrinsic Pathway for Apoptosis pathway
REACT_219580
Activation of BAD and translocation to mitochondria pathway
REACT_219672
Opioid Signalling pathway
REACT_216714
Innate Immune System pathway
REACT_225357
Fc epsilon receptor (FCERI) signaling pathway
REACT_219454
Apoptosis pathway
KEGG
hsa04370
VEGF signaling pathway pathway
hsa04310
Wnt signaling pathway pathway
hsa04210
Apoptosis pathway
hsa04010
MAPK signaling pathway pathway
hsa04360
Axon guidance pathway
hsa04720
Long-term potentiation pathway
hsa05010
Alzheimer's disease pathway
hsa04662
B cell receptor signaling pathway pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa04020
Calcium signaling pathway pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
hsa04114
Oocyte meiosis pathway
hsa04380
Osteoclast differentiation pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
Cross-References
SwissProt Q63810
TrEMBL
UniProt Splice Variant
Entrez Gene 19058
UniGene Mm.401506 Mm.41840 Mm.474050
RefSeq NM_024459
OMIM
CCDS CCDS24448
HPRD
IMGT
MGI ID MGI:107172
MGI Symbol Ppp3r1
EMBL AK133403 AK145541 AK160938 AK163241 AL606466 AL713926 S43864
GenPept AAB23171 BAE21637 BAE26495 BAE36102 BAE37251 CAI51912 CAI51920
RNA Seq Atlas 19058

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca