InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppargc1b

Summary

InnateDB Protein

IDBP-151807.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppargc1b

Protein Name

peroxisome proliferative activated receptor, gamma, coactivator 1 beta

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074771

InnateDB Gene

IDBG-151805 (Ppargc1b)

Protein Structure

UniProt Annotation

Function

Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta- oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Induces also the expression of mitochondrial genes involved in oxidative metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269PubMed:11733490, ECO:0000269PubMed:12678921, ECO:0000269PubMed:14530391, ECO:0000269PubMed:15680331}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous with higher expression in heart, brown adipose tissue, brain and skeletal muscle. {ECO:0000269PubMed:11733490, ECO:0000269PubMed:12678921}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0030331	estrogen receptor binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0030546	receptor activator activity
GO:0050682	AF-2 domain binding

Biological Process

GO:0001503	ossification
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006390	transcription from mitochondrial promoter
GO:0007015	actin filament organization
GO:0010694	positive regulation of alkaline phosphatase activity
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0034614	cellular response to reactive oxygen species
GO:0042327	positive regulation of phosphorylation
GO:0045087	innate immune response (InnateDB)
GO:0045672	positive regulation of osteoclast differentiation
GO:0045780	positive regulation of bone resorption
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP
GO:0060346	bone trabecula formation
GO:2000273	positive regulation of receptor activity